Great mountain range! Both times I went to the same area because I'm a lazy bum and I figure the Big Sandy trailhead is by far the closest and easiest access to the core of the range. In 1999 there were maybe a dozen cars parked at the trailhead. In 2015, same time of year, there were 80 or 100. Humanity is no longer sparse there! And there were a lot of parties with paid climbing guides. But it's still fabulous. In hindsight, I think the driving time might not be all that much longer to the Lander side, and I kind of wish I had checked that out.
If you're worried about grizzlies, I think they are sparse there compared to Tetons, YS, or Glacier. But ask the rangers, don't take my word for it.
This forum is used to share your experiences out on the trails.