I use the same combination. I have very wide feet with a narrow heel and trail runners that are wide enough for my toes allow my foot to slide around inside, which makes for very unstable footing.
I can't say why, but I'm fortunate to NEVER have blisters, my Lowa Renegades are hot and my feet sweat in them which is uncomfortable, but I don't get blisters. I don't like the fact that my feet are hot, but I really like the waterproof factor which keep my feet dry when sloshing through streams and mud. I just air them out at night, along with my Smartwool socks. No bad smell either. I'm guessing you just have to find the right fit. My feet don't slide around and I have no heel lift.